Repeat arrays in cellular DNA related to the Epstein-Barr virus IR3 repeat.
نویسندگان
چکیده
منابع مشابه
Epstein-Barr virus DNA. X. Direct repeat within the internal direct repeat of Epstein-Barr virus DNA.
The 3,360-base-pair internal direct repeat (IR) in Epstein-Barr virus DNA separates the short and long unique DNA domains. IR has a single BamHI site. The juncture between the short unique domain and IR has been mapped by restriction endonucleases and is less than 2,600 nucleotides before the BamHI site in IR. The junction between IR and the long unique domain has been sequenced and is approxim...
متن کاملEpstein-Barr Virus DNA Replication
Epstein-Barr virus (EBV) and its close relatives are the only known viruses that have two fully independent systems for replicating their genomes, one that supports virus production during active or "lytic" infection, and a second one that operates during latent stages of infection to allow the circular viral genomes to be duplicated during each cell division cycle. Although EBV's system of lyt...
متن کاملmRNA translation regulation by the Gly-Ala repeat of Epstein-Barr virus nuclear antigen 1.
The glycine-alanine repeat (GAr) sequence of the Epstein-Barr virus-encoded EBNA-1 prevents presentation of antigenic peptides to major histocompatibility complex class I molecules. This has been attributed to its capacity to suppress mRNA translation in cis. However, the underlying mechanism of this function remains largely unknown. Here, we have further investigated the effect of the GAr as a...
متن کاملAnalyses of non-coding RNAs generated from the Epstein-Barr virus W repeat region
Introduction: The Epstein–Barr virus (EBV) W repeats are transcribed during viral lytic reactivation, a highly oncogenic form of latency known as latency III, and a rare type of latency (Wp-restricted) that is observed in ~15% of endemic Burkitt’s lymphomas. The W repeats encode an EBV protein, EBNA-LP, whose message is produced by splicing out a short (81 nt) and long (2791 nt) intron. We prev...
متن کاملBZLF1 controlled by family repeat domain induces lytic cytotoxicity in Epstein-Barr virus-positive tumor cells.
BACKGROUND BZLF1, an EBV (Epstein-Barr virus) immediate early gene, is required for EBV lytic replication that causes the death of host cells. EBNA1, the product of EBV latent gene, binds to the family repeats (FR) of the origin of replication (Orip) regulating EBV replication. MATERIALS AND METHODS A vector pFR-Z (BZLF1 controlled by FR domain of EBV) was constructed and transfected into EBV...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 1985
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.5.3.457